Monthly Archives: July 2016

Day 182 (8pter-8p23.1): a cluster of defensins

f3-largehttp://pediatrics.aappublications.org/content/125/6/1237

Day 182 has 45 protein-coding genes (browser view), including 18 defensin genes.

These are small secreted proteins that kill and control fungi, bacteria, and viruses.

Click here to see all 8537566 letters of Day 182

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Day 183 (8p23.1-8p22): cathepsin B

figure-3-the-lysosome-rupture-model-of-nlrp3-inflammasome-activationcrystalline-orhttps://www.researchgate.net/figure/41486952_fig4_Figure-3-The-lysosome-rupture-model-of-NLRP3-inflammasome-activationCrystalline-or

Day 183 has 41 protein-coding genes (browser view) including cathepsin B (CTSB).

Like Day 102 (4q34.1-4q34.3): aspartylglucosaminidase, cathepsin B is a lysosomal protease. It is overactive in many cancers.

Click here to see all 8537567 letters of Day 183 with CTSB underlined.

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Day 184 (8p22-8p21.2): hairless

alopecia-totalishttp://medical-dictionary.thefreedictionary.com/alopecia+totalis

Day 184 has 69 protein-coding genes (browser view) including HR (HR, lysine demethylase and nuclear receptor corepressor).

HR was formerly known as “hair growth associated,” and was named “hairless” when found in mice. Mutations cause alopecia, so the normal role must be in hair growth.

Click here to see all 8537567 letters of Day 184 with HR underlined.

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Day 185 (8p21.2-8p12): the fossil of a gene that used to make vitamin C

vitamin-chttp://drwillard.com/blog/2015/01/all-you-need-to-know-about-vitamin-c/

Day 185 has 47 protein-coding genes (browser view) and a very important pseudogene: GULOP.

The GULO pseudogene is a gene that used to give us the ability to synthesize Vitamin C. The broken, nonfunctional vestige of the gene remains in our genome and is a beautiful demonstration of evolution.

Click here to see all 8537567 letters of Day 185 with GULOP underlined.

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Day 186 (8p12-8p11.21): tPA, an un-clotter

image4http://www.intechopen.com/books/fibrinolysis-and-thrombolysis/an-insight-into-the-abnormal-fibrin-clots-its-pathophysiological-roles

Day 186 has 48 protein-coding genes (browser view) including PLAT (plasminogen activator, tissue).

Tissue plasminogen activator (tPA) is a natural signal to break down clots. It can be given as a drug for stroke and heart attack.

Click here to see all 8537566 letters of Day 186 with PLAT underlined.

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Day 187 (8p11.21-8q11.21): a nicotinic receptor

smokinghttp://www.mirror.co.uk/news/uk-news/uks-smoking-capital-revealed-how-6759245

Day 187 has 18 protein-coding genes (browser view) including CHRNB3 (Neuronal acetylcholine receptor subunit beta-3).

This gene encodes part of a nACHr, whose natural job in the brain is to respond to a neurotransmitter, but which can also be turned on by nicotine.

Click here to see all 8537567 letters of Day 187 with CHRNB3

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Day 188 (8q11.21-8q12.1): kappa opioid receptor, target of salvia

800px-salvia_divinorum_-1https://en.wikipedia.org/wiki/Salvia_divinorum#/media/File:Salvia_divinorum_-1.jpg

Day 188 has 32 protein-coding genes (browser view), including OPKR1 (kappa-opioid receptor).

Like Day 143 (6q25.2-6q26): the mu opiod receptor, OPKR1 is an opioid receptor in the brain, but behaves differently. It may actually counteract the addictive mechanisms of the other opioid receptors. It is specifically targeted by the psychoactive plant salvia which is important to Aztec and Mazatec religious practice.

Click here to see all 8537567 letters of Day 188 with OPKR1 underlined.

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Day 189 (8q12.1-8q13.2): CRH, a stress signal within the brain

pbb_protein_crh_imagehttps://en.wikipedia.org/wiki/Corticotropin-releasing_hormone#/media/File:PBB_Protein_CRH_image.jpg

Day 189 has 34 protein-coding genes (browser view) including CRH (corticotropin-releasing hormone).

This is a tiny protein hormone, secreted by one part of the brain (the hypothalamus) in response to stress, and received by another part of the brain, the pituitary.

Click here to see all 8537567 letters of Day 189 with CRH underlined.

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Day 190 (8q13.2-8q21.13): an elongin

500px-protein_tceb1_pdb_1lm8https://en.wikipedia.org/wiki/TCEB1

Day 190 has 29 protein-coding genes (browser view) including ELOC (elongin C).

This gene has changed names in the past year – it was called TCEB1 at the beginning of 2016. It encodes one of the elongin proteins which help RNA polymerase transcribe genes from DNA.

Click here to see all 8537566 letters of Day 190 with ELOC underlined.

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Day 191 (8q21.13-8q21.2): interleukin 7, a signal to make lymphoblasts

f6-largehttp://www.bloodjournal.org/content/99/11/3892?sso-checked=true

Day 191 has 30 protein-coding genes (browser view), including IL7 (interleukin 7).

It is a signal for stem cells to mature into lymphoblasts, which then become different kinds of cells in the immune system.

Click here to see all 8537567 letters of Day 191 with IL7 underlined.

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