Monthly Archives: October 2016

Day 274 (13q31.3-13q32.2): a gene desert with critical oncomirs

ijms-14-17085f2-1024http://www.mdpi.com/1422-0067/14/8/17085/htm

Day 274 has 16 protein-coding genes (browser view) and some of the best-studied microRNA genes: mir-17 and mir-92.

Like we saw nearby on Day 269 (13q14.2-13q21.1): two cancer-suppressing microRNAs, these genes are important in development and cancer. While those microRNAs were tumor suppressors, these are oncomirs – microRNAs that promote normal growth of cells and tumors.

Click here to see all 8168881 letters of Day 274 with MIR17 underlined.

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Day 275 (13q32.2-13q33.2): SLC15A1, getting protein from your diet

vital_ingredients_artwork-copy1http://www.rivertea.com/blog/protein-supplements-vs-natural-proteins-who-wins-the-battle/

Day 275 has 28 protein-coding genes (browser view) including SLC15A1 (solute carrier family 15 member 1).

SLC15A1 is a transporter that allows your intestines to take up dietary protein.

Click here to see all 8168880 letters of Day 275 with SLC15A1 underlined.

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Day 276 (13q33.2-13qter): two clotting factors

f1-largehttp://physrev.physiology.org/content/93/1/327

Day 276 has 41 protein-coding genes (browser view) including F10 and F7 (coagulation factors X and VII).

Like Factor III on Day 12 (1p21.3-1p21.1): Tissue factor, a protein that senses bleeding, Factor VII and Factor X are involved with clotting. Unsurprisingly for two genes in the same neighborhood, they are expressed on the same cells.

Click here to see all 8168881 letters of Day 276 with F7 underlined.

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Day 277 (14pter-14p11.2): Chromosome 14, another acrocentric chromosome

human_chromosome_14_-_550_bphshttps://en.wikipedia.org/wiki/Chromosome_14_(human)

Day 277 has no protein-coding genes (browser view). It is the beginning of Chromosome 14, which is one of the five acrocentric chromosomes with a very short gene-poor p arm.

Click here to see all 8234132 letters of Day 277.

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Day 278 (14p11.2-14p11.1): No genes again today; more cool stuff about Chromosome 14

slide_31http://slideplayer.com/slide/4894370/

Day 278 has no protein-coding genes (browser view).

Chromosome 14 is interesting because it is one of the chromosomes where it’s not ok to accidentally get both copies from the same parent (uniparental disomy). This means there may be more important imprinted genes on Chromosome 14 compared to other chromosomes.

Click here to see all 8234132 letters of Day 278.

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Day 279 (14p11.1-14q12): The other big T-cell receptor locus

screen-shot-2017-01-02-at-11-19-35-am

Day 279 has 153 protein-coding genes (browser view) including the T-cell receptor alpha and delta locus.

Along with what we saw on Day 149 (7p14.3-7p14.1): The T cell receptor gamma locus, this is the other main site where T-cells shuffle their DNA to make a diverse set of immune recetors

Click here to see all 8234132 letters of Day 279 with TRAC (T-cell receptor alpha constant) underlined.

 

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Day 280 (14q12-14q13.1): cochlin

ORhttp://www.medel.com/blog/photographic-tour-of-the-cochlea/

Day 280 has 19 protein-coding genes (browser view) including COCH (cochlin).

Not much has been written about cochlin, but it is expressed in the inner ear, and mutations have been associated with deafness.

Click here to see all 8234132 letters of Day 280 with COCH underlined.

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Day 281 (14q13.1-14q21.1): a lung surfactant

rkybvprhttp://imgur.com/gallery/RKyBVPr

Day 281 has 36 protein-coding genes (browser view) including SFTA3 (surfactant assocaited 3).

SFTA3 was discovered in 2014. It is found in the lungs and may function as one of the pulmonary surfactant proteins that allow lung “compliance” – the ability to expand or contract.

Click here to see all 8234132 letters of Day 281 with SFTA3 underlined.

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Day 282 (14q21.1-14q21.3): a mystery lincRNA

screen-shot-2017-01-02-at-1-43-52-pm

Day 282 has 11 protein-coding genes (browser view), and like most days, has many poorly-understood lincRNAs, including LINC00648 (long intergenic noncoding RNA 648).

Like Day 47 (2q22.2-2q23.3): VIS1, a mysterious noncoding RNA, LINC00648 is uncharacterized.

Click here to see all 8234132 letters of Day 282 with LINC00648 underlined.

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Day 283 (14q21.3-14q23.1): a galectin

protein_lgals3_pdb_1a3khttps://en.wikipedia.org/wiki/Galectin-3#/media/File:Protein_LGALS3_PDB_1a3k.png

Day 283 has 61 protein-coding genes (browser view) including LGALS3 (lectin, galactoside-binding, soluble, 3), a.k.a. galectin 3.

Galectins are proteins that can bind to sugars. This particular galectin is expressed in many tissues, and both inside and outside of the cells. It is correlated with many normal and disease processes.

Click here to see all 8234132 letters of Day 283 with LGALS3 underlined.

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