Day 100 (4q32.1-4q32.3): GRIA1, a crucial bit of A-to-I editing

 

F1.largehttp://www.biochemsoctrans.org/content/37/6/1399

 

Day 100 has 24 protein-coding genes (browser view) including the gene for GRIA2 (glutamate receptor 2), a neurotransmitter.

GRIA2 is an interesting case of RNA editing: some of the adenosine (A) bases in the mRNA for GRIA2 are chemically modified by an enzyme to become inosine (I) Рwhich makes the ribosome read them as a G instead of an A. This editing is decreased in the neurons of ALS patients, which may be one of the mechanisms of neuron death.

Click here to see all 8646116 letters of Day 100 with GRIA2 underlined.

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