Day 123 (5q34-5q35.1): numatrin, a trigger for the cell’s skeleton to divide

Immunocytochemistry/ Immunofluorescence - Nucleophosmin antibody (ab37659)http://www.abcam.com/nucleophosmin-antibody-ab37659.html#description_images_2

Day 123 has 28 protein-coding genes (browser view), including the gene for numatrin aka nucleophosmin, NPM1.

Numatrin was discovered in 1988, and is a protein that sticks to the “skeleton” of the cell’s nucleus (the nuclear matrix). It “turns on” right before the entire cell’s skeleton splits in two during cell division. Accordingly, it is mutated in many cancers.

Click here to see all 8644679 letters of Day 123, with NPM1 underlined.

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