Day 124 (5q35.1-5qter): sequestosome 1

1034771399pagets1http://www.seniorfootcare.com.au/pagets-disease-of-bone/

Day 124 has 102 protein-coding genes (browser view) including sequestosome 1 (SQSTM1).

Sequestosome 1 was so¬†named because it can sequester proteins that have been tagged for destruction, pulling them into autophagosomes, where they are then sent to be digested. SQSTM1 mutations have been implicated in many diseases including Paget’s disease of bone.

Click here to see all 8644679 letters of Day 124, with the Paget’s disease mutation P392L flashing.

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