Day 128 (6p22.2-6p21.31): the remarkable HLA locus

5-be_the_match-matching_donors_with_patientshttps://bethematch.org/transplant-basics/matching-patients-with-donors/how-donors-and-patients-are-matched/

Day 128 has 277 protein-coding genes (browser view). This very crowded region contains hundreds of genes that form the human leukocyte antigen (HLA) complex.

The HLA genes encode proteins that the immune system uses to distinguish between self and foreign cells. They were discovered through studying graft rejection and the HLA region is used to determine transplant compatibility. The HLA region is extraordinarily diverse between humans as a result of balancing selection.

Click here to see all 8540299 letters of Day 128, with one of the HLA genes HLA-DRB1 underlined.

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