Day 152 (7p11.1-7q11.21): SBDS, an ancient gene next to a troublesome fossil


Day 152 has 25 protein-coding genes (browser view) including SBDS (Shwachman-Bodian-Diamond syndrome). 

SBDS helps build ribosomes, and mutations cause a rare developmental syndrome. Interestingly, it is a genetic fossil nearby – a pseudogene that looks like SBDS – that sometimes confuses the cell during replication, damaging the “living” SBDS gene through gene conversion.

SBDS is present even in Archaea, meaning it is billions of years old.

Click here to see all 8386630 letters of Day 152 with SBDS underlined.

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