Day 250 (12p12.1-12p11.1): a potent cancer switch in KRAS

image041http://www.pathologyoutlines.com/topic/stainskras.html

Day 250 has 44 protein-coding genes (browser view) including KRAS (Kirsten rat sarcoma viral oncogene homolog).

KRAS is a growth-stimulating gene, so activating mutations can cause cancer. The gene’s name comes from the fact that it was discovered in a rat RNA virus¬†that co-opts the gene to cause cancer (the virus was discovered by W.H. Kerstin in 1967¬†and the ras oncogene was characterized in 1982)

Click here to see all 8329707 letters of Day 250 with the G12D mutation flashing – the most common mutation in ovarian cancer.

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