Day 250 (12p12.1-12p11.1): a potent cancer switch in KRAS

image041http://www.pathologyoutlines.com/topic/stainskras.html

Day 250 has 44 protein-coding genes (browser view) including KRAS (Kirsten rat sarcoma viral oncogene homolog).

KRAS is a growth-stimulating gene, so activating mutations can cause cancer. The gene’s name comes from the fact that it was discovered in a rat RNA virus that co-opts the gene to cause cancer (the virus was discovered by W.H. Kerstin in 1967 and the ras oncogene was characterized in 1982)

Click here to see all 8329707 letters of Day 250 with the G12D mutation flashing – the most common mutation in ovarian cancer.

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