Day 299 (15q24.3-15q25.3): a smoking behavior locus

smoking-1418483_1280https://pixabay.com/en/smoking-cigarette-smoke-unhealthy-1418483/

Day 299 has 73 protein-coding genes (browser view), including CHRNA3, CHRNA4, and CHRNA5 (cholinergic receptor, nicotinic alpha 3, 4, and 5).

Like we saw on Day 187 (8p11.21-8q11.21): a nicotinic receptor, these three genes encode receptors in your brain that respond to nicotine. Variants here have been shown to associate with how much different people like to smoke. In turn, these variants are associated with lung cancer and COPD.

Click here to see all 8499265 letters of Day 299 with CHRNA3 underlined.

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