Day 308 (16q12.1-16q21): a SNP in FTO, the strongest determinant of obesity

Fatso_posterhttps://en.wikipedia.org/wiki/Fatso_(1980_film)

Day 308 has 63 protein-coding genes (browser view) including FTO (FTO, alpha-ketoglutarate dependent dioxygenase).

A variant in the FTO gene is the strongest genetic association with obesity.

The name’s origin was unexpectedly prescient. Per Wikipedia:

Peters et al. (1999) cloned a novel gene from a region of several hundred kb deleted by the mouse ‘fused toes’ (FT) mutation. They named the gene ‘fatso’ (Fto) due to its large size.

Click here to see all 8212577 letters of Day 308 with the rs1421085 obesity SNP flashing.

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