http://www.billfrymire.com/gallery/isthmus-Central-America.jpg.html Isthmus of Central America
Day 333 has 18 protein-coding genes (browser view) including ISM1 (isthmin 1, angiogenesis inhibitor).
Isthmin was discovered in mouse, and named for an isthmus-shaped boundary in the brain where it was found. It sends a signal to stop blood vessel growth during development.
Click here to see all 8055521 letters of Day 333 with ISM1 underlined.