Day 42 (2q12.1-2q12.3): a gene desert and a MAP kinase kinase kinase kinase gene

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Day 42 has 40 protein-coding genes (browser view).  You can see from the browser view that there is a gene desert of about 2 million bases in the middle of the day with no protein-coding (orange) genes.

One gene to the left of the desert is MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). What is a protein kinase kinase kinase kinase?

Protein kinases are proteins that add phosphorous atoms to other proteins. Usually this is part of a signaling cascade – a protein is phosphorylated by a protein kinase, which was phosphorylated by a protein kinase kinase, which was phosphorylated by a protein kinase kinase kinase, which was phosphorylated by a protein kinase kinase kinase kinase… etc.

Click here for a nucleotide-level view of Day 42, jumping to your MAP4K4 gene.

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