Day 82 (4pter-4p16.1): the start of chromosome 4; huntingtin

https://en.wikipedia.org/wiki/Huntingtons_disease#/media/File:On_Chorea_with_photo.jpg

Day 82 has 94 protein-coding genes (browser view) at the beginning of the p arm of Chromosome 4. It includes the famous huntingtin gene.

A mutated form of the huntingtin gene causes Huntington’s disease, but the normal roleĀ of the protein is unclear. Because the disease is associated with more repeats of a CAG sequence in the gene, Huntington’s is a trinucleotide repeat disorder. Read this story about the discovery of the huntingtin gene.

Click here to see all 8646116 letters of Day 82 with the huntingtin repeat flashing.

 

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