Day 93 (4q22.3-4q24): an Asian innovation in alcohol dehydrogenase


Day 93 has 37 protein-coding genes (browser view) including several genes that make alcohol dehydrogenases, including ADH1B.

A variant in AHD1B, rs1229984 (H48R) is one of the unusual variants that is highly differentiated between populations: it is present in almost all people of Asian descent and is rare in others. It decreases alcohol clearance in the liver and is thought to have evolved recently along with rice cultivation, possibly as a defense against alcoholism. As expected, people with the mutation have a lower risk of oral/throat cancers.

Click here to see all 8646116 letters of Day 93 with the H48R mutation flashing.

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