Tag Archives: RNAi

Day 5 (1p34.3-1p34.2): Argonaute

“Argonauta argo Merculiano” by Comingio Merculiano (1845–1915) in Jatta Giuseppe – I Cefalopodi viventi nel Golfo di Napoli (sistematica) : monografia. Licensed under Public Domain via Commons – https://commons.wikimedia.org/wiki/File:Argonauta_argo_Merculiano.jpg#/media/File:Argonauta_argo_Merculiano.jpg

Day 5 has 108 protein-coding genes, including AGO1 (argonaute 1 RISC catalytic component.) Argonaute is an critical part of the cell’s RNA interference (RNAi) machinery.

Fire and Mello won the 2006 Nobel Prize in Physiology or Medicine for their characterization of RNAi using the nematode C. elegans in 1998, but the gene Argonaute got its name from a group working in the plant A. thaliana. They named the gene family Argonaute because mutations in the plant’s version of the genes led to an appearance that reminded them of a small squid, and named it after the octopus Argonauta argo.

Argonaute proteins are ancient: even bacteria have a version of them, which they use to chew up foreign DNA as a defense against viruses.

Click here to see your human version of AGO1.

Leave a Comment

Filed under Uncategorized